Designing New Cellular Signaling Pathways
نویسندگان
چکیده
منابع مشابه
The roles of EPIYA sequence to perturb the cellular signaling pathways and cancer risk
Abstract It was shown that several pathogenic bacterial effector proteins contain the Glu-Pro-Ile-Tyr-Ala (EPIYA) or a similar sequence. These bacterial EPIYA effectors are delivered into host cell via type III or IV secretion system, where they undergo tyrosine phosphorylation at the EPIYA sequences, which triggers interaction with multiple host cell SH2 domain-containing proteins and thereby...
متن کاملCellular Signaling Pathways in Alcoholic Liver Disease
The pathogenesis of acute and chronic alcohol consumption is complex with diverse consequences in different tissues. Alcohol abuse is associated with a continuum of liver abnormalities ranging from steatosis or fat deposition, steatohepatitis or fat plus inflammation to cirrhosis and hepatocellular carcinoma. The progression of alcohol-induced liver damage involves both parenchymal and non-pare...
متن کاملStorytelling and Clustering for Cellular Signaling Pathways
In this paper, we describe our recent work on graph mining as applied to the cellular signaling pathways in the Signal Transduction Knowledge Environment (STKE) [1]. We present new algorithms and a graphical tool that can help biologists discover relationships between pathways by looking at structural overlaps within the database. We address the problem of determining pathway relationships by t...
متن کاملNew connections between old pathways: PDK1 signaling promotes cellular transformation through PLK1-dependent MYC stabilization.
Limited understanding of the functional link between multiple oncogenic pathways is a major barrier in the ongoing effort of cancer biologists to design an effective therapeutic approach to treat malignancies characterized by driver oncogenic network signals. In this issue of Cancer Discovery, Tan and colleagues elucidate a novel PDK1-PLK1-MYC signaling pathway connecting two fundamental oncoge...
متن کاملMitogen-activated protein kinases: new signaling pathways functioning in cellular responses to environmental stress.
The mitogen-activated protein kinase (MAPK) superfamily consists of three main protein kinase families: the extracellular signal-regulated protein kinases (ERKs), the c-Jun N-terminal kinases (JNKs) and the p38 family of kinases. Each is proving to have major roles in the regulation of intracellular metabolism and gene expression and integral actions in many areas including growth and developme...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 2009
ISSN: 1074-5521
DOI: 10.1016/j.chembiol.2009.01.011